The trouble started when supporters of the Al-Ahly football club chanted slogans against Mubarak and former interior minister Habib al-Adli, both on trial for murder, and threw bottles at police, police and witnesses said.
The clashes moved to a nearby street, police said, where the fans wounded 72 policemen and torched more than a dozen cars, including four police vehicles.
Seven civilians were wounded and police arrested 12 protesters, they added.
Witnesses said the clashes began when policemen tried to forcibly remove the fans, who chanted anti-Mubarak slogans after the match.
Mubarak, ousted in a popular uprising in February, is on trial with Adli and six police commanders on charges of ordering the shootings of protesters during the revolt.
Mubarak’s two sons Alaa and Gamal are defendants in the same trial on graft charges. The trial resumes on Wednesday.