On a visit to Broughton, Mr Cameron said the deal was “excellent news and a tremendous boost” for UK manufacturing.
The company says a $9bn (£5.5bn) order for 100 A320 planes from AirAsia will safeguard 1,500 Airbus jobs in the UK and 7,500 in its supply chain.
The wings for its A320 series are made at the Flintshire factory.
AirAsias’s order is for 64 of the A320neo (new engine option) and 36 of the A320ceo (current engine option) aircraft.
Mr Cameron toured the wing assembly plant on Thursday with AirAsia group chief executive officer, Tan Sri Dr Tony Fernandes.
Dr Fernandes said: “The A320 has played a key role in our success, enabling us to offer our passengers the lowest fares possible and completely redefine short-haul travel in Asia.”