It has signed an agreement with a Burmese firm to distribute Pepsi-Cola, 7-Up and Mirinda brands in the country.
PepsiCo, which pulled out of Burma in 1997, said it was also exploring the option of setting up production there.
The firm’s rival Coca-Cola has also announced plans to return to Burma.
“We are constantly looking for new growth opportunities that will put our food and beverage brands in the hands of more consumers,” said PepsiCo chairman and chief executive Indra Nooyi.
Ms Nooyi added that Burma was “a market with great potential” and “over time, we believe we can build a strong business” in the country.
The drinks maker has been expanding its operations in developing and emerging markets.
Its revenues from these economies nearly tripled to $22bn (£15bn) in 2011 from $8bn in 2006.